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IGF-1 LR3

IGF-1 LR3

Advanced muscle growth factor

$250/mo

Virtual consult + lab work required

This peptide requires a brief virtual visit and recent bloodwork before our team can prescribe.

Details

Virtual Consult

Our licensed provider reviews your health profile via secure video — typically 10 minutes. Required for any peptide prescription.

Required Labs

  • IGF-1
  • Glucose
  • Insulin

Refund Policy: If found not eligible due to health reasons after consultation, you will receive a full refund.

Product Details

About IGF-1 LR3

Mechanism of Action

IGF-1 LR3 is a modified IGF-1 with 83 amino acids and reduced binding to IGFBPs (90% less), extending half-life to 20-30 hours vs 10-12 hours for native IGF-1. It activates the PI3K-Akt-mTOR pathway for protein synthesis, stimulates satellite cell proliferation for muscle repair and hyperplasia (new muscle fiber formation), and promotes fat oxidation.

Scientific Background

The LR3 variant was developed to overcome native IGF-1's short half-life and extensive protein binding. Research shows it's approximately three times more potent than native IGF-1 for cellular proliferation. Uniquely capable of promoting both hypertrophy (fiber enlargement) and hyperplasia (new fiber formation).

Clinical Applications

Used for advanced muscle development and recovery. Typically cycled 4-6 weeks on, 4 weeks off to prevent receptor downregulation. Can be injected locally into trained muscle groups for targeted effects. Requires monitoring for hypoglycemic effects due to increased glucose uptake.

Evidence-Based

Clinical Research & Studies

Backed by peer-reviewed research from leading medical journals

1996
Peer Reviewed

Long R3 IGF-I stimulates muscle growth and protein synthesis

Study demonstrating IGF-1 LR3 stimulates skeletal muscle protein synthesis and reduces protein degradation, resulting in significant increases in muscle mass independent of growth hormone.

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2004
Peer Reviewed

IGF-1 promotes satellite cell proliferation and myogenic differentiation

Research showing IGF-1 activates satellite cells and promotes their differentiation into mature muscle fibers, providing mechanism for hyperplastic muscle growth and enhanced recovery.

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2010
Peer Reviewed

Effects of IGF-1 on muscle regeneration and hypertrophy

Comprehensive review of IGF-1's role in muscle development, demonstrating its critical importance for muscle hypertrophy, regeneration after injury, and maintenance of muscle mass.

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Educational Articles

Article

IGF-1 LR3: Advanced Muscle Building and Recovery

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Article

Understanding Growth Factors in Peptide Therapy

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