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MOTS-c

MOTS-c

Mitochondrial metabolic optimizer

$275/mo

Virtual consult required

This peptide requires a brief virtual visit before our team can prescribe.

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Refund Policy: If found not eligible due to health reasons after consultation, you will receive a full refund.

Product Details

About MOTS-c

Mechanism of Action

MOTS-c is a 16-amino acid peptide encoded by mitochondrial DNA that acts as a metabolic regulator through mitochondrial-nuclear signaling. It activates the AMPK pathway—the body's "metabolic master switch"—promoting glucose uptake independent of insulin, enhancing fatty acid oxidation, and improving mitochondrial function. MOTS-c also reduces adipose tissue inflammation and prevents age-related insulin resistance.

Scientific Background

Discovered in 2015, MOTS-c naturally declines with age, contributing to metabolic dysfunction and insulin resistance. Research shows it mimics beneficial effects of exercise and caloric restriction at the molecular level. Genetic variants in the MOTS-c coding region are associated with exceptional longevity, particularly in Japanese centenarians.

Clinical Applications

MOTS-c shows promise for metabolic syndrome, type 2 diabetes, obesity, and age-related decline. Research demonstrates its ability to reverse insulin resistance, reduce body fat, and improve exercise capacity. The peptide is also being investigated for protecting against sarcopenia and neurodegenerative conditions.

Evidence-Based

Clinical Research & Studies

Backed by peer-reviewed research from leading medical journals

2015
Peer Reviewed

A mitochondrially encoded hormone, MOTS-c, regulates skeletal muscle and metabolic homeostasis

Landmark study identifying MOTS-c and demonstrating its ability to prevent diet-induced obesity and insulin resistance in mice by targeting skeletal muscle metabolism and enhancing glucose uptake.

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2019
Peer Reviewed

MOTS-c improves insulin sensitivity by activating the AMPK pathway

Research showing MOTS-c improves glucose metabolism and insulin sensitivity through AMPK activation, with significant reductions in obesity-induced inflammation and metabolic dysfunction.

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2021
Peer Reviewed

Exercise-induced MOTS-c expression and its role in age-related metabolic decline

Study demonstrating that MOTS-c levels increase with exercise and supplementation can restore youthful metabolic function in aged mice, improving muscle function and extending healthspan.

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Educational Articles

Article

Mitochondrial Peptides: The Future of Metabolic Health

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Article

MOTS-c and Longevity: Science-Backed Anti-Aging Strategies

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