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SS-31

SS-31

Mitochondrial protection peptide

$250/mo

Virtual consult required

This peptide requires a brief virtual visit before our team can prescribe.

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Virtual Consult

Our licensed provider reviews your health profile via secure video — typically 10 minutes. Required for any peptide prescription.

Refund Policy: If found not eligible due to health reasons after consultation, you will receive a full refund.

Product Details

About SS-31

Mechanism of Action

SS-31 (Elamipretide) is a tetrapeptide that concentrates in the inner mitochondrial membrane at up to 5,000-fold higher than cytoplasm levels. It binds and protects cardiolipin, a phospholipid crucial for electron transport chain function. By preventing cardiolipin oxidative damage, SS-31 optimizes ATP synthesis, reduces ROS production, and preserves mitochondrial membrane integrity.

Scientific Background

Developed at Cornell University as a breakthrough in mitochondria-targeted therapeutics. Addresses the fundamental aging mechanism of mitochondrial dysfunction. Clinical trials conducted for Barth syndrome, primary mitochondrial myopathy, and heart failure. Research shows it can restore energetics in aged tissues and extend healthspan in animal models.

Clinical Applications

Used for age-related mitochondrial decline, cardiovascular disease, chronic fatigue, and athletic performance. Particularly valuable for endurance performance since mitochondrial function limits aerobic capacity. Often combined with NAD+ and MOTS-c for comprehensive longevity protocols. Effects on energy noticeable within days to weeks.

Evidence-Based

Clinical Research & Studies

Backed by peer-reviewed research from leading medical journals

2013
Peer Reviewed

SS-31 ameliorates age-associated mitochondrial dysfunction

Study demonstrating SS-31 treatment in aged mice improved mitochondrial energetics, reduced ROS production, and enhanced physical performance, suggesting potential for treating age-related mitochondrial decline.

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2019
Peer Reviewed

Elamipretide improves mitochondrial function in Barth syndrome

Clinical trial showing SS-31 improved exercise capacity, cardiac function, and quality of life in patients with Barth syndrome, a genetic disorder affecting cardiolipin, validating the peptide's mechanism of action.

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2014
Peer Reviewed

Cardiolipin-targeted peptide SS-31 protects against mitochondrial dysfunction

Research revealing SS-31 selectively binds cardiolipin, stabilizes mitochondrial cristae, reduces ROS generation, and protects against various forms of mitochondrial injury and dysfunction.

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Educational Articles

Article

SS-31: Mitochondrial Optimization for Energy and Longevity

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Article

Understanding Mitochondrial Health and Aging

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